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李英霞 教授

 李英霞  教授                                           

李英霞

性别

出生年月

19644

最终学历

研究生

教授

51980127

 

博士

室主任

51980127

所在院系

药学院

E-mail

Liyx417@fudan.edu.cn

通信地址(邮编)

浦东新区张衡路826

               

  主讲课程:

《高等药物化学》,硕士研究生专业基础课,18学时/,2年,25

《高等有机化学》,硕士研究生专业基础课,6学时/,1年,10

《糖化学》,博士研究生专业基 础课,36学时/年,3年,22

《有机波谱解析》,本科选修课,108学时/年,2,112

《药物化学》,本科专业科,4-18学时,2年,70

主持的研究课题:

1.海洋肽类BACE1抑制剂的结构优化与活性研究,国家自然基金面上项目,2012-2015.

2.抗肿瘤咔唑糖苷的成药性评价,863主题项目子课题,2011-2014.

3.皂苷类高致病性禽流感病毒H5N1进入抑制剂的构效关系研究国家自然基金面上项目,2010-2013

4.高致病性禽流感病毒H5N1进入抑制剂的成药性研究,上海市优秀学术带头人计划,2011-2013.

5.雷公藤红素十六醇酯静脉乳注射液的临床前研究,国家新药创制重大专项,2008-2011.

 

代表性文章:

 

 

 

1. Mingming Zhang, Weiliang Zhu, Yingxia Li*. Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. European Journal of Medicinal Chemistry 2013, 62, 301-310.

2. Mingming Zhang, Weiliang Zhu, Ning Ding, Wei Zhang,Yingxia Li*. Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. Bioorganic & Medicinal Chemistry Letters 2013, 23, 2225-2229.

3. Yanxia Liu, Wei Zhang, Li Li, Lilibeth A. Salvador, Tiantian Chen, Wuyan Chen, Kevin M. Felsenstein,  Thomas B. Ladd, Ashleigh R. Price, Todd E. Golde, Jianhua He, Yechun Xu*, Yingxia Li*, Hendrik Luesch*. Journal of Medicinal Chemistry 2012, 55, 10749-10765.

4. Siming Yang, Wei Zhang, Ning Ding, Jeannette Lo, Yanxia Liu, Michael J. Clare-Salzler, Hendrik Luesch,* Yingxia Li*. Total synthesis of grassystatin A, a probe for cathepsin E function. Bioorganic & Medicinal Chemistry 2012, 20, 4774-4780.

5. Ning Ding, Qing Chen, Wei Zhang, Sumei Ren, Ying Guo*, Yingxia Li*. Structure-activity relationships of saponin derivatives: a series inhibitors on highly pathogenic H5N1 influenza viral entry. European Journal of Medicinal Chemistry 2012, 53, 316-326.

6. Dakuo Shi, Wei Zhang, Ning Ding, Ming Li*, Yingxia Li*. Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors. European Journal of Medicinal Chemistry 2012, 47, 424-431.

7. Zhichao Lu , Ning Ding, Wei Zhang, Peng Wang, Yingxia Li*, A convenient synthesis of  the core trisaccharide of the N-glycans. Tetrahedron Letters 2011, 52, 3320-3323.

8. Guangfa Wang, Wei Zhang, Zhichao Lu, Peng Wang, Xiuli Zhang, and Ying xia Li*, Convenient Synthesis of an N-Glycan Octasaccharide of the Bisecting Type. Journal of Organic Chemistry 2009, 74, 2508-2515.

9. Gaopeng Song, Sen Yang, Wei Zhang, Yingli Cao, Peng Wang, Ning Ding, Zaihong Zhang, Ying Guo* and Yingxia Li*, Discovery of the First Series of Small Molecule H5N1 Entry Inhibitors. Journal of Medicinal Chemistry 2009, 52, 7368–7371.